I just watched this episode of DTown TV (an online show with Scott Kelby) and he and Matt Kloskowski discuss what settings the change when they buy a new Nikon dSLR. ; I found that many of the settings were still set to factory settings for my D300. ; The logic behind changing them made sense so I made the changes on my camera. I'm finding that I really like this online series http://www.dtowntv.com/2009/05/episode-11/
I agree, if you own any of the current Nikon models, this podcast is a must. ; The commercials are even fun.
As a side note, D-Town isn't focusing on Nikon products this season like they did in the past, making it a better resource for all photographers.